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The remaining patients needed to increase the dosage, by steps of 0.03Â mg/kg/day, until reaching an average effective dosage of 0.1Â mg/kg/day. An initial dosage of 0.05Â mg/kg/day was sufficient for 41% of the patients. The causes of high blood pressure were renal tumor (n=7), catecholamine-secreting tumor (n=4), corticoid treatment (n=5), and cyclosporine treatment (n=23). Thirty-nine hypertensive children (age: 0.13-14Â years) receiving lacidipine in oncohematology for a mean of 75Â days were included in this retrospective study. Until now, no data on the efficacy or safety of this calcium antagonist have been available in children. This particular characteristic makes it advantageous when combined with drugs metabolized by CYP3A4, such as cyclosporine. In adults, lacidipine seems to have no CYP3A4-inhibiting action. īernard, E Mialou, V Dony, A Garnier, N Renard, C Bleyzac, N flavus infection/colonization in the investigated onco-hematology unit. These findings strongly suggest the occurrence of hospital-acquired A. Two main transmission scenarios were observed: (1) the same clone was isolated from different patients (2) the same clone was isolated from a patient, its hospital environment and/or food. The remaining 42 isolates showed a unique genotype. The genotyping of 18 clinical isolates, collected from sputa of 17 acute leukemia patients, and 81 isolates, collected in these patients' hospital environment and food, identified 57 isolates that were grouped in 10 clones, each of them including 2-17 isolates. flavus strains to assess whether IA could be hospital-acquired in the onco-hematology unit of the Farhat Hached teaching hospital of Sousse, Tunisia. We used five highly discriminative microsatellite markers for the genotyping of clinical and hospital environmental A. The molecular epidemiology of the species is poorly documented.

Gheith, Soukeina Saghrouni, Fatma Normand, Anne-CÃ©cile Bannour, Wadiaa Khelif, Abderrahim Piarroux, Renaud Ben Said, Moncef Njah, Mansour Ranque, StÃ©phaneĪspergillus flavus is the most common species associated with invasive aspergillosis in Tunisia. Microsatellite Typing of Aspergillus flavus Strains in a Tunisian Onco-hematology Unit.

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